New paper

Together with Misa Hirose from the Ibrahim lab in Lübeck we investigated the role of mtDNA polymorphisms as a modifier of healthspan in mice. The study has been published in IJMS as part of the Special Issue mtDNA and Mitochondrial Stress Signaling in Human Diseases.In this study, we provide experimental evidence that a maternally inherited…

New paper

Our study of the cutaneous microbiome in psoriasis got published in the British Journal of Dermatology.The treatment of psoriasis has been revolutionised by the development of biologic therapies. However, the pathogenesis of psoriasis, in particular the role of the cutaneous microbiome, remains incompletely understood. Moreover, skin microbiome studies have heavily relied on 16S rRNA sequencing…

Dietary ursolic acid improves health span and life span in male Drosophila melanogaster

Primary bile acids are produced in the liver, whereas secondary bile acids, such as lithocholic acid (LCA), are generated by gut bacteria from primary bile acids that escape the ileal absorption. Besides their well-known function as detergents in lipid digestion, bile acids are important signaling molecules mediating effects on the host’s metabolism. The whole paper…

IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid

IL-17A has been identified as key regulatory molecule in several autoimmune and chronic inflammatory diseases followed by the successful use of anti-IL-17 therapy, e.g. in ankylosing spondylitis and psoriasis. Bullous pemphigoid (BP) is the most frequent autoimmune blistering disease with a high need for more specific, effective and safe treatment options. The aim of this…