Welcome to website of the Group for Medical Systems Biology

The Medical Systems Biology group focuses on the computational investigation and integration of multi-omics data in explorative, preventative, and therapeutic contexts.

About us
We deploy concepts from non-linear dynamics and complex systems to develop mathematical models that unravel the self-organizing principles behind the interactions with biological entities.
Team

The complementary experience and research emphases of our team allow integrating all scales of resolution from genetic code to phenotypic expression.

Meet The Team

Service & Research Units

In the medical context, we work in cooperation with clinical facilities and research groups in the exploration of disease etiology, identification of pathways , and the development of treatment options in personalized medicine.

Bioinformatics Service Unit

We can advise on project planning to clarify at an early stage whether specific scientific questions can be answered within your experimental planning to avoid future complications.

Single Cell Core Facility

New sequencing technologies have revolutionized genome research over the last decade.

Systems Genetics

We work towards a systems level understanding of biological organisms by investigating the relationship between the genome and phenotypic and molecular traits as well as disease using computational methods.

Cancer Research Unit

What are the molecular drivers in tumor progression? How can current methods of molecular medicine, sequencing, and machine learning in the clinical diagnostics and routine be transferred?

Projects

A particular focus is put on the field of cancer research which culminated in the design of computational diagnostics pipelines for the Molecular Tumor Board at the UKSH Lübeck, which is an interface between clinical treatment and cutting-edge scientific insights by applying state-of-the-art sequencing and analysis approaches to the most challenging cases.

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News and publications

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Jul17

New publication in molecularly adjusted therapy upon identification and functional validation

Molecular tumor board: molecularly adjusted therapy upon identification and functional validation of a novel ALK resistance mutation in a case of lung adenocarcinoma
Jul17

New publication in cBioPortal

Prototypical Visualization of Patient Similarities in cBioPortal to Enhance Decision-Making in Molecular Tumor Boards
Jul17

New publication in Secretory IgA (sIgA)

DOP030 Mucosal deficiency of mitochondria-driven humoral immunity is linked to Crohn’s Disease
Jul17

New publication in Empowering personalized oncology

Empowering personalized oncology: evolution of digital support and visualization tools for molecular tumor boards
Jul17

New publication in Endoplasmic Reticulum Proteins

Endoplasmic Reticulum Proteins Impact Penetrance in a Pink1-Mutant Drosophila Model

Career

Join the Medical Systems Biology group

The group for Medical Systems Biology focuses on the development and verification of mathematical models for cellular behavior and cell communication from an initial stimulus to the final phenotype.

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