About us
We deploy concepts from non-linear dynamics and complex systems to develop mathematical models that unravel the self-organizing principles behind the interactions with biological entities.

The complementary experience and research emphases of our team allow integrating all scales of resolution from genetic code to phenotypic expression.


A particular focus is put on the field of cancer research which culminated in the design of computational diagnostics pipelines for the Molecular Tumor Board at the UKSH Lübeck, which is an interface between clinical treatment and cutting-edge scientific insights by applying state-of-the-art sequencing and analysis approaches to the most challenging cases.

News and publications

Successfull Habilitation by Sven Stefan

On July 2nd Sven held his “Antrittsvorlesung”, the last requirement to obtain his venia legendi, the right to teach, from the University of Lübeck! Congratulations!

New publication in The Oncologist

Molecular tumor board: molecularly adjusted therapy upon identification and functional validation of a novel ALK resistance mutation in a case of lung adenocarcinoma

New publication in Leukemia

Clonal evolution and blastic plasmacytoid dendritic cell neoplasm: malignancies of divergent hematopoietic lineages emerging from a common founding clone

New publication in Journal of Investigative Dermatology

Intravenous Ig Ameliorates Disease in a Murine Model of Anti–Laminin 332 Mucous Membrane Pemphigoid

New publication in Leukemia

Genome-wide DNA methylation-analysis of blastic plasmacytoid dendritic cell neoplasm identifies distinct molecular features


Join the Medical Systems Biology group

The group for Medical Systems Biology focuses on the development and verification of mathematical models for cellular behavior and cell communication from an initial stimulus to the final phenotype.