Systems Genetics
We work towards a systems level understanding of biological organisms by investigating the relationship between the genome and phenotypic and molecular traits as well as disease using computational methods. Towards this, our focus lies on the analysis of data obtained from high throughput sequencing, with special emphasis on long read sequencing as the most accurate technology.
Topics
Current collaborations
Miscellaneous
Topics
- Transcriptome analyses (RNA-Seq, Nanopore direct RNA sequencing)
- RNA modification detection from Nanopore data
- Linking genetic variants to gene expression (eQTLs)
- Genetic variant identification (small and structural variant calling from short and long read sequencing data)
- Mitochondrial variant identification and analyses (haplogroups, phylogenetics)
- Genome-wide association studies (GWAS) related analyses: polygenic risk scores, functional fine mapping, haplotypes
Current collaborations
- Institute for Cardiogenetics, University of Lübeck
- Institute of Neurogenetics, University of Lübeck
- Genetics Division, Lübeck Institute of Experimental Dermatology, University of Lübeck
- Ancient DNA Lab, CAU Kiel
- Genetics & Bioinformatics, CAU Kiel
- Algorithmic Bioinformatics, Saarbrücken University
- Department of Systems Biology and Bioinformatics, University of Rostock
- College of Medicine, University of Sharjah, The United Arab Emirates
- The American University in Cairo (AUC), Egypt
Miscellaneous
- Participate in the article collection: Long read sequencing – pitfalls, benefits and success stories!
- We organize a monthly Nanopore user group meeting, please get in contact if you are interested to join!
- BSc or MSc theses for the above topics are available, please send us an e-mail if you are interested!