Svenja Denker

• Computational Biologist
• Ph.D. student in project M07 (Multi-Omics Analysis of Sex Variability) of the CRC 1665 – Sexdiversity

• Svenja Denker graduated in Molecular Life Science at the University of Lübeck in 2022. During her studies, she developed a keen interest in oncology as well as in data analysis and bioinformatics. She did her Master’s thesis in the research group bioinformatics at the Max Planck Institute for Evolutionary Biology in Plön under the supervision of Professor Dr. Bernhard Haubold.
• Since 2023 she has been working in the medical system biology group where she mainly focuses on analyzing sequencing data from cancer projects.
• In 2024, she started working on her doctoral thesis. This thesis is in the project M07 – Multi-Omics Analysis of Sex Variability of the Collaborative Research CentreSexdiversity – Determinants, meanings and implications of sex diversity in socio-cultural, medical and biological landscapes (SFB 1665).

• Vieira Mourato, B.; Tsers, I.; Denker, S.; Klötzl, F.; Haubold, B. Marker Discovery in the Large. Bioinformatics Advances 2024, vbae113. https://doi.org/10.1093/bioadv/vbae113.
• Denker, S.; Künstner, A.; Schwarting, J.; Witte, H. M.; Bernard, V.; Stölting, S.; Lohneis, P.; Kusch, K.; Von Bubnoff, N.; Merz, H.; Busch, H.; Feller, A. C.; Gebauer, N. Clonal Evolution and Blastic Plasmacytoid Dendritic Cell Neoplasm: Malignancies of Divergent Hematopoietic Lineages Emerging from a Common Founding Clone. Leukemia 2024, 38 , 1858–1861. https://doi.org/10.1038/s41375-024-02305-8.

References:

1. Rehmann-Sutter, C., Hornig, N., Stammberger, B., & Stoff, H. (2023). The past and future of “sex genes.” Medizinische Genetik, 35(3), 153–161. https://doi.org/10.1515/medgen-2023-2040
2. Al-Sharkawi, M., Calonga-Solís, V., Dressler, F. F., Busch, H., Hiort, O., & Werner, R. (2023). Persistenceof foetal testicular features in patients with defectiveandrogen signalling.European Journal ofEndocrinology, 188(1), 166–175. https://doi.org/10.1093/ejendo/lvad007
3. Sohni, A., Tan, K., Song, H.-W., Burow, D., de Rooij, D. G., Laurent, L., Hsieh, T.-C., Rabah, R., Hammoud, S. S., Vicini, E., & Wilkinson, M. F. (2019). The Neonatal and Adult Human Testis Defined at theSingle-Cell Level. Cell Reports, 26(6), 1501-1517.e4. https://doi.org/10.1016/j.celrep.2019.01.045
4. Guo, J., Grow, E. J., Mlcochova, H., Maher, G. J., Lindskog, C., Nie, X., Guo, Y., Takei, Y., Yun, J., Cai, L., Kim, R., Carrell, D. T., Goriely, A., Hotaling, J. M., & Cairns, B. R. (2018). The adult human testistranscriptional cell atlas.Cell Research, 28(12), 1141–1157. https://doi.org/10.1038/s41422-018-0099-2
5. Guo, J., Nie, X., Giebler, M., Mlcochova, H., Wang, Y., Grow, E. J., Kim, R., Tharmalingam, M., Matilionyte, G., Lindskog, C., Carrell, D. T., Mitchell, R. T., Goriely, A., Hotaling, J. M., & Cairns, B. R. (2020). The Dynamic Transcriptional Cell Atlas ofTestis Development during Human Puberty.Cell StemCell, 26(2), 262-276.e4. https://doi.org/10.1016/j.stem.2019.12.005
6. Guo, J., Sosa, E., Chitiashvili, T., Nie, X., Rojas, E. J., Oliver, E., Plath, K., Hotaling, J. M., Stukenborg, J.-B., Clark, A. T., & Cairns, B. R. (2021). Single-cellanalysis of the developing human testis revealssomatic niche cell specification and fetal germlinestem cell establishment. Cell Stem Cell, 28(4), 764-778.e4. https://doi.org/10.1016/j.stem.2020.12.004