Niklas Reimer
Ph.D. Candidate
Medizinisches Datenintegrationszentrum (MeDIC) Teamleiter „Refinement“ – Universitätsklinikum Schleswig-Holstein
Position and responsibilities
Scientific profile
Selected Publications
Position and responsibilities
- Health Information interoperability
- Omics pipeline development
- Omics data integration
- Metadata guided data integration
- UKSH/UzL PM4Onco
- UKSH Medical Data Integration Center (MeDIC)
- UCCSH Molecular Tumor Board
Scientific profile
Niklas Reimer graduated in Medical Informatics at the Universität zu Lübeck in 2020. Since then, he has been a member of the Group for Medical Systems Biology and is involved in the development of IT solutions for the molecular tumor board of the University Cancer Center Schleswig-Holstein. He works closely with the MIRACUM consortium and the IT Center for Clinical Research, Universität zu Lübeck.
CV
Scientific career
- since 2024 Research Associate, Medical Data Integration Center (MeDIC), University Hospital Schleswig-Holstein, Campus Lübeck
- since 2020 Research Associate, Medical Systems Biology, Lübeck Institute of Experimental Dermatology, Universität zu Lübeck
- 2019 – 2020 Master of Science (Medical Informatics), Universität zu Lübeck
- 2015 – 2019 Bachelor of Science (Medical Informatics), Universität zu Lübeck
Memberships
- Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS)
- Gesellschaft für Informatik (GI)
- Verband der Elektrotechnik Elektronik Informationstechnik (VDE)
Selected Publications
7575694
HKKZERLJ
1
american-chemical-society
50
date
desc
1105
https://medsysbio-luebeck.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22K7Z79UTP%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bossenz%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-15%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BBossenz%2C%20J.%3B%20Manuilova%2C%20I.%3B%20Weise%2C%20A.%20B.%3B%20Schulze%2C%20S.%3B%20Hiemer%2C%20S.%3B%20Eszlinger%2C%20M.%3B%20Boerries%2C%20M.%3B%20Busch%2C%20H.%3B%20Boehm%2C%20D.%3B%20Unberath%2C%20P.%3B%20Reimer%2C%20N.%3B%20Strantz%2C%20C.%3B%20Christoph%2C%20J.%20Prototypical%20Visualization%20of%20Patient%20Similarities%20in%20CBioPortal%20to%20Enhance%20Decision-Making%20in%20Molecular%20Tumor%20Boards.%20In%20%26lt%3Bi%26gt%3BStudies%20in%20Health%20Technology%20and%20Informatics%26lt%3B%5C%2Fi%26gt%3B%3B%20Andrikopoulou%2C%20E.%2C%20Gallos%2C%20P.%2C%20Arvanitis%2C%20T.%20N.%2C%20Austin%2C%20R.%2C%20Benis%2C%20A.%2C%20Cornet%2C%20R.%2C%20Chatzistergos%2C%20P.%2C%20Dejaco%2C%20A.%2C%20Dusseljee-Peute%2C%20L.%2C%20Mohasseb%2C%20A.%2C%20Natsiavas%2C%20P.%2C%20Nakkas%2C%20H.%2C%20Scott%2C%20P.%2C%20Eds.%3B%20IOS%20Press%2C%202025.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3233%5C%2FSHTI250385.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22bookSection%22%2C%22title%22%3A%22Prototypical%20Visualization%20of%20Patient%20Similarities%20in%20cBioPortal%20to%20Enhance%20Decision-Making%20in%20Molecular%20Tumor%20Boards%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Elisavet%22%2C%22lastName%22%3A%22Andrikopoulou%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Parisis%22%2C%22lastName%22%3A%22Gallos%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Theodoros%20N.%22%2C%22lastName%22%3A%22Arvanitis%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Rosalynn%22%2C%22lastName%22%3A%22Austin%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Arriel%22%2C%22lastName%22%3A%22Benis%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Ronald%22%2C%22lastName%22%3A%22Cornet%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Panagiotis%22%2C%22lastName%22%3A%22Chatzistergos%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Dejaco%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Dusseljee-Peute%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Alaa%22%2C%22lastName%22%3A%22Mohasseb%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Pantelis%22%2C%22lastName%22%3A%22Natsiavas%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Haythem%22%2C%22lastName%22%3A%22Nakkas%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Scott%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Bossenz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iryna%22%2C%22lastName%22%3A%22Manuilova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annemarie%20Bianka%22%2C%22lastName%22%3A%22Weise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susann%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%22%2C%22lastName%22%3A%22Hiemer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Eszlinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Boerries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominik%22%2C%22lastName%22%3A%22Boehm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Unberath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cosima%22%2C%22lastName%22%3A%22Strantz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Christoph%22%7D%5D%2C%22abstractNote%22%3A%22Background%3A%20Patient%20similarity%20analysis%20is%20pivotal%20in%20cancer%20research%20and%20clinical%20oncology%2C%20aiding%20in%20identifying%20patterns%20among%20patients%20with%20similar%20clinical%20and%20molecular%20profiles%20to%20guide%20therapeutic%20decisions%2C%20particularly%20in%20Molecular%20Tumor%20Boards%20%28MTB%29%2C%20where%20therapy%20decisions%20are%20frequently%20informed%20by%20the%20treatment%20experiences%20of%20previously%20treated%20similar%20patients.%20However%2C%20the%20lack%20of%20standardized%20tools%20for%20automation%20and%20visualization%20limits%20efficiency%20here%2C%20especially%20in%20individualized%20MTB%20decisions.%20Objective%3A%20This%20study%20aims%20to%20develop%20a%20graphical%20user%20interface%20that%20aligns%20with%20clinician%20preferences%20to%20enhance%20patient%20similarity%20assessments%20and%20support%20decision-making%20in%20MTBs.%20Methods%3A%20Visualization%20concepts%20were%20developed%20through%20iterative%20design%20and%20evaluation%20cycles%20involving%20clinical%20experts.%20Mock-ups%20were%20created%20to%20represent%20various%20approaches%20for%20displaying%20patient%20similarities%2C%20focusing%20on%20molecular%20data%20relevant%20to%20MTB%20decisions.%20Results%3A%20Various%20designs%20were%20developed%20for%20visualizing%20patient%20similarity%20in%20cBioPortal.%20These%20include%20tabular%20views%2C%20network%20representations%2C%20and%20radar%20plots.%20Conclusions%3A%20These%20visualizations%20offer%20promise%20in%20enhancing%20decision-making%20in%20MTBs%20by%20making%20patient%20similarity%20assessments%20more%20accessible.%20Future%20development%20will%20focus%20on%20additional%20functionalities%20and%20better%20integration%20into%20clinical%20workflows.%22%2C%22bookTitle%22%3A%22Studies%20in%20Health%20Technology%20and%20Informatics%22%2C%22date%22%3A%222025-05-15%22%2C%22language%22%3A%22%22%2C%22ISBN%22%3A%22978-1-64368-596-0%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Febooks.iospress.nl%5C%2Fdoi%5C%2F10.3233%5C%2FSHTI250385%22%2C%22collections%22%3A%5B%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222025-05-20T08%3A33%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22JJMNBSRK%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Boehm%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-15%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BBoehm%2C%20D.%3B%20Reimer%2C%20N.%3B%20Christoph%2C%20J.%3B%20Scheiter%2C%20A.%3B%20Unberath%2C%20P.%20Building%20a%20Knowledge%20Base%20for%20Variant%20Annotation%20Using%20Therapy%20Recommendations%20in%20CBioPortal.%20In%20%26lt%3Bi%26gt%3BStudies%20in%20Health%20Technology%20and%20Informatics%26lt%3B%5C%2Fi%26gt%3B%3B%20Andrikopoulou%2C%20E.%2C%20Gallos%2C%20P.%2C%20Arvanitis%2C%20T.%20N.%2C%20Austin%2C%20R.%2C%20Benis%2C%20A.%2C%20Cornet%2C%20R.%2C%20Chatzistergos%2C%20P.%2C%20Dejaco%2C%20A.%2C%20Dusseljee-Peute%2C%20L.%2C%20Mohasseb%2C%20A.%2C%20Natsiavas%2C%20P.%2C%20Nakkas%2C%20H.%2C%20Scott%2C%20P.%2C%20Eds.%3B%20IOS%20Press%2C%202025.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3233%5C%2FSHTI250281.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22bookSection%22%2C%22title%22%3A%22Building%20a%20Knowledge%20Base%20for%20Variant%20Annotation%20Using%20Therapy%20Recommendations%20in%20cBioPortal%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Elisavet%22%2C%22lastName%22%3A%22Andrikopoulou%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Parisis%22%2C%22lastName%22%3A%22Gallos%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Theodoros%20N.%22%2C%22lastName%22%3A%22Arvanitis%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Rosalynn%22%2C%22lastName%22%3A%22Austin%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Arriel%22%2C%22lastName%22%3A%22Benis%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Ronald%22%2C%22lastName%22%3A%22Cornet%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Panagiotis%22%2C%22lastName%22%3A%22Chatzistergos%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Dejaco%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Dusseljee-Peute%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Alaa%22%2C%22lastName%22%3A%22Mohasseb%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Pantelis%22%2C%22lastName%22%3A%22Natsiavas%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Haythem%22%2C%22lastName%22%3A%22Nakkas%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Philip%22%2C%22lastName%22%3A%22Scott%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominik%22%2C%22lastName%22%3A%22Boehm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Christoph%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Scheiter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Unberath%22%7D%5D%2C%22abstractNote%22%3A%22Molecular%20tumor%20boards%20present%20special%20challenges%20when%20it%20comes%20to%20information%20collection%20for%20case%20preparation.%20It%20is%20one%20of%20the%20most%20time-consuming%20tasks%20participating%20pathologists%20and%20oncologists%20face%2C%20limiting%20the%20number%20of%20cases%20that%20can%20be%20discussed%20in%20these%20specialized%20tumor%20boards%20and%20in%20turn%20can%20profit%20from%20a%20potential%20highly%20personalized%20therapy.%20Digital%20support%20is%20a%20necessity%20to%20enable%20medical%20professionals%20to%20efficiently%20make%20use%20of%20the%20vast%20amount%20of%20data%20available%20for%20each%20patient%20and%20their%20genomic%20and%20clinical%20profile.%20This%20includes%20historically%20recommended%20therapies%20for%20patients%20with%20molecularly%20similar%20tumors.%20To%20combat%20this%20issue%2C%20we%20developed%20an%20extension%20for%20the%20MTB-cBioPortal%20in%20collaboration%20with%20clinicians%2C%20enabling%20users%20to%20access%20previously%20documented%20therapy%20recommendations%20combined%20with%20corresponding%20follow-up%20data%20based%20on%20HL7%20FHIR%20profiles%20and%20modules%20established%20in%20the%20Medical%20Informatics%20Initiative%20%28MII%29.%20The%20information%20is%20made%20available%20through%20an%20additional%20annotation%20in%20the%20MTB-cBioPortal%20patient%20view.%20In%20doing%20so%20we%20intend%20to%20improve%20the%20efficiency%20of%20the%20case%20preparation%20process%20for%20molecular%20tumor%20boards%20and%20lay%20the%20groundwork%20for%20a%20potential%20multicentric%20exchange%20of%20therapy%20recommendations%20and%20follow-up%20data.%22%2C%22bookTitle%22%3A%22Studies%20in%20Health%20Technology%20and%20Informatics%22%2C%22date%22%3A%222025-05-15%22%2C%22language%22%3A%22%22%2C%22ISBN%22%3A%22978-1-64368-596-0%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Febooks.iospress.nl%5C%2Fdoi%5C%2F10.3233%5C%2FSHTI250281%22%2C%22collections%22%3A%5B%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222025-05-20T08%3A32%3A53Z%22%7D%7D%2C%7B%22key%22%3A%225EU76XI8%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schladetzky%20et%20al.%22%2C%22parsedDate%22%3A%222024-08-22%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BSchladetzky%2C%20J.%3B%20Reimer%2C%20N.%3B%20Nicolaus%2C%20H.%3B%20Busch%2C%20H.%3B%20Schreiweis%2C%20B.%3B%20Kock-Schoppenhauer%2C%20A.-K.%20Integration%20of%20Oncological%20Data%20into%20OpenEHR%3A%20A%20Path%20Towards%20Improved%20Cancer%20Care%20and%20Research.%20In%20%26lt%3Bi%26gt%3BStudies%20in%20Health%20Technology%20and%20Informatics%26lt%3B%5C%2Fi%26gt%3B%3B%20Mantas%2C%20J.%2C%20Hasman%2C%20A.%2C%20Demiris%2C%20G.%2C%20Saranto%2C%20K.%2C%20Marschollek%2C%20M.%2C%20Arvanitis%2C%20T.%20N.%2C%20Ognjanovi%26%23×107%3B%2C%20I.%2C%20Benis%2C%20A.%2C%20Gallos%2C%20P.%2C%20Zoulias%2C%20E.%2C%20Andrikopoulou%2C%20E.%2C%20Eds.%3B%20IOS%20Press%2C%202024.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3233%5C%2FSHTI240655.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22bookSection%22%2C%22title%22%3A%22Integration%20of%20Oncological%20Data%20into%20openEHR%3A%20A%20Path%20Towards%20Improved%20Cancer%20Care%20and%20Research%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Mantas%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Arie%22%2C%22lastName%22%3A%22Hasman%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22George%22%2C%22lastName%22%3A%22Demiris%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Kaija%22%2C%22lastName%22%3A%22Saranto%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Marschollek%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Theodoros%20N.%22%2C%22lastName%22%3A%22Arvanitis%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Ivana%22%2C%22lastName%22%3A%22Ognjanovi%5Cu0107%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Arriel%22%2C%22lastName%22%3A%22Benis%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Parisis%22%2C%22lastName%22%3A%22Gallos%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Emmanouil%22%2C%22lastName%22%3A%22Zoulias%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Elisavet%22%2C%22lastName%22%3A%22Andrikopoulou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Schladetzky%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Herwig%22%2C%22lastName%22%3A%22Nicolaus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bj%5Cu00f6rn%22%2C%22lastName%22%3A%22Schreiweis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ann-Kristin%22%2C%22lastName%22%3A%22Kock-Schoppenhauer%22%7D%5D%2C%22abstractNote%22%3A%22The%20integration%20of%20tumor-related%20diagnosis%20and%20therapy%20data%20is%20a%20key%20factor%20for%20cancer-related%20collaborative%20projects%20and%20research%20projects%20on-site.%20The%20Medical%20Data%20Integration%20Center%20%28MeDIC%29%20of%20the%20University%20Hospital%20Schleswig-Holstein%2C%20resulting%20from%20the%20Medical%20Informatics%20Initiative%20and%20Network%20University%20Medicine%20in%20Germany%2C%20has%20agreed%20on%20an%20openEHR-based%20data%20management%20based%20on%20a%20centralized%20repository%20with%20harmonized%20annotated%20data.%20Consequently%2C%20the%20oncological%20data%20should%20be%20integrated%20into%20the%20MeDIC%20to%20interconnect%20the%20information%20and%20thus%20gain%20added%20value.%20A%20uniform%20national%20data%20set%20for%20tumor-related%20reports%20is%20already%20defined%20for%20the%20cancer%20registries.%20Therefore%2C%20this%20work%20aims%20to%20transform%20the%20national%20oncological%20basis%20data%20set%20for%20tumor%20documentation%20%28oBDS%29%20so%20that%20it%20can%20be%20stored%20and%20utilized%20properly%20in%20the%20openEHR%20repository%20of%20the%20MeDIC.%20In%20a%20previous%20work%20openEHR%20templates%20representing%20the%20oncological%20basis%20data%20set%20were%20modeled.%20These%20templates%20were%20used%20to%20implement%20a%20processing%20pipeline%20including%20a%20metadata%20repository%2C%20which%20defines%20the%20mappings%20between%20the%20elements%2C%20a%20FHIR%20terminology%20service%20for%20annotation%20and%20validation%2C%20resulting%20in%20a%20tool%20to%20automatically%20build%20openEHR%20compositions%20from%20oBDS%20data.%20The%20prototype%20proved%20the%20feasibility%20of%20the%20referred%20mapping%2C%20integration%20into%20the%20MeDIC%20is%20straightforward%20and%20the%20architecture%20introduced%20is%20adaptable%20to%20future%20needs%20by%20design.%22%2C%22bookTitle%22%3A%22Studies%20in%20Health%20Technology%20and%20Informatics%22%2C%22date%22%3A%222024-08-22%22%2C%22language%22%3A%22%22%2C%22ISBN%22%3A%229781643685335%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Febooks.iospress.nl%5C%2Fdoi%5C%2F10.3233%5C%2FSHTI240655%22%2C%22collections%22%3A%5B%22L242IFDH%22%2C%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222024-09-03T09%3A36%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22AI2P37WV%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Renner%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-11%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BRenner%2C%20C.%3B%20Reimer%2C%20N.%3B%20Christoph%2C%20J.%3B%20Busch%2C%20H.%3B%20Metzger%2C%20P.%3B%20Boerries%2C%20M.%3B%20Ustjanzew%2C%20A.%3B%20Boehm%2C%20D.%3B%20Unberath%2C%20P.%20Extending%20CBioPortal%20for%20Therapy%20Recommendation%20Documentation%20in%20Molecular%20Tumor%20Boards%3A%20Development%20and%20Usability%20Study.%20%26lt%3Bi%26gt%3BJMIR%20Med%20Inform%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B2023%26lt%3B%5C%2Fb%26gt%3B%2C%20%26lt%3Bi%26gt%3B11%26lt%3B%5C%2Fi%26gt%3B%2C%20e50017.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2196%5C%2F50017%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2196%5C%2F50017%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Extending%20cBioPortal%20for%20Therapy%20Recommendation%20Documentation%20in%20Molecular%20Tumor%20Boards%3A%20Development%20and%20Usability%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22Renner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Christoph%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Metzger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Boerries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arsenij%22%2C%22lastName%22%3A%22Ustjanzew%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominik%22%2C%22lastName%22%3A%22Boehm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Unberath%22%7D%5D%2C%22abstractNote%22%3A%22Background%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20molecular%20tumor%20boards%20%28MTBs%29%2C%20patients%20with%20rare%20or%20advanced%20cancers%20are%20discussed%20by%20a%20multidisciplinary%20team%20of%20health%20care%20professionals.%20Software%20support%20for%20MTBs%20is%20lacking%3B%20in%20particular%2C%20tools%20for%20preparing%20and%20documenting%20MTB%20therapy%20recommendations%20need%20to%20be%20developed.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objective%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20aimed%20to%20implement%20an%20extension%20to%20cBioPortal%20to%20provide%20a%20tool%20for%20the%20documentation%20of%20therapy%20recommendations%20from%20MTB%20sessions%20in%20a%20secure%20and%20standardized%20manner.%20The%20developed%20extension%20should%20be%20embedded%20in%20the%20patient%20view%20of%20cBioPortal%20to%20enable%20easy%20documentation%20during%20MTB%20sessions.%20The%20resulting%20architecture%20for%20storing%20therapy%20recommendations%20should%20be%20integrable%20into%20various%20hospital%20information%20systems.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20On%20the%20basis%20of%20a%20requirements%20analysis%20and%20technology%20analysis%20for%20authentication%20techniques%2C%20a%20prototype%20was%20developed%20and%20iteratively%20refined%20through%20a%20user-centered%20development%20process.%20In%20conclusion%2C%20the%20tool%20was%20evaluated%20via%20a%20usability%20evaluation%2C%20including%20interviews%2C%20structured%20questionnaires%2C%20and%20the%20System%20Usability%20Scale.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20patient%20view%20of%20cBioPortal%20was%20extended%20with%20a%20new%20tab%20that%20enables%20users%20to%20document%20MTB%20sessions%20and%20therapy%20recommendations.%20The%20role-based%20access%20control%20was%20expanded%20to%20allow%20for%20a%20finer%20distinction%20among%20the%20rights%20to%20view%2C%20edit%2C%20and%20delete%20data.%20The%20usability%20evaluation%20showed%20overall%20good%20usability%20and%20a%20System%20Usability%20Scale%20score%20of%2083.57.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20This%20study%20demonstrates%20how%20cBioPortal%20can%20be%20extended%20to%20not%20only%20visualize%20MTB%20patient%20data%20but%20also%20be%20used%20as%20a%20documentation%20platform%20for%20therapy%20recommendations.%22%2C%22date%22%3A%222023-12-11%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.2196%5C%2F50017%22%2C%22ISSN%22%3A%222291-9694%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fmedinform.jmir.org%5C%2F2023%5C%2F1%5C%2Fe50017%22%2C%22collections%22%3A%5B%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222023-12-12T16%3A52%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22VUXJAZY8%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Metzger%20et%20al.%22%2C%22parsedDate%22%3A%222023-07-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BMetzger%2C%20P.%3B%20Hess%2C%20M.%20E.%3B%20Blaumeiser%2C%20A.%3B%20Pauli%2C%20T.%3B%20Schipperges%2C%20V.%3B%20Mertes%2C%20R.%3B%20Christoph%2C%20J.%3B%20Unberath%2C%20P.%3B%20Reimer%2C%20N.%3B%20Scheible%2C%20R.%3B%20Illert%2C%20A.%20L.%3B%20Busch%2C%20H.%3B%20Andrieux%2C%20G.%3B%20Boerries%2C%20M.%20MIRACUM-Pipe%3A%20An%20Adaptable%20Pipeline%20for%20Next-Generation%20Sequencing%20Analysis%2C%20Reporting%2C%20and%20Visualization%20for%20Clinical%20Decision%20Making.%20%26lt%3Bi%26gt%3BCancers%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B2023%26lt%3B%5C%2Fb%26gt%3B%2C%20%26lt%3Bi%26gt%3B15%26lt%3B%5C%2Fi%26gt%3B%20%2813%29%2C%203456.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fcancers15133456%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fcancers15133456%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22MIRACUM-Pipe%3A%20An%20Adaptable%20Pipeline%20for%20Next-Generation%20Sequencing%20Analysis%2C%20Reporting%2C%20and%20Visualization%20for%20Clinical%20Decision%20Making%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Metzger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20Elena%22%2C%22lastName%22%3A%22Hess%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Blaumeiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Pauli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Schipperges%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ralf%22%2C%22lastName%22%3A%22Mertes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Christoph%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Unberath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raphael%22%2C%22lastName%22%3A%22Scheible%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20L.%22%2C%22lastName%22%3A%22Illert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geoffroy%22%2C%22lastName%22%3A%22Andrieux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Boerries%22%7D%5D%2C%22abstractNote%22%3A%22%281%29%20Background%3A%20Next-generation%20sequencing%20%28NGS%29%20of%20patients%20with%20advanced%20tumors%20is%20becoming%20an%20established%20method%20in%20Molecular%20Tumor%20Boards.%20However%2C%20somatic%20variant%20detection%2C%20interpretation%2C%20and%20report%20generation%2C%20require%20in-depth%20knowledge%20of%20both%20bioinformatics%20and%20oncology.%20%282%29%20Methods%3A%20MIRACUM-Pipe%20combines%20many%20individual%20tools%20into%20a%20seamless%20workflow%20for%20comprehensive%20analyses%20and%20annotation%20of%20NGS%20data%20including%20quality%20control%2C%20alignment%2C%20variant%20calling%2C%20copy%20number%20variation%20estimation%2C%20evaluation%20of%20complex%20biomarkers%2C%20and%20RNA%20fusion%20detection.%20%283%29%20Results%3A%20MIRACUM-Pipe%20offers%20an%20easy-to-use%2C%20one-prompt%20standardized%20solution%20to%20analyze%20NGS%20data%2C%20including%20quality%20control%2C%20variant%20calling%2C%20copy%20number%20estimation%2C%20annotation%2C%20visualization%2C%20and%20report%20generation.%20%284%29%20Conclusions%3A%20MIRACUM-Pipe%2C%20a%20versatile%20pipeline%20for%20NGS%2C%20can%20be%20customized%20according%20to%20bioinformatics%20and%20clinical%20needs%20and%20to%20support%20clinical%20decision-making%20with%20visual%20processing%20and%20interactive%20reporting.%22%2C%22date%22%3A%222023-07-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3390%5C%2Fcancers15133456%22%2C%22ISSN%22%3A%222072-6694%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2072-6694%5C%2F15%5C%2F13%5C%2F3456%22%2C%22collections%22%3A%5B%22L242IFDH%22%2C%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222023-07-05T08%3A14%3A22Z%22%7D%7D%2C%7B%22key%22%3A%22D6ELT5CE%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Witte%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BWitte%2C%20H.%20M.%3B%20Riedl%2C%20J.%3B%20K%26%23xFC%3Bnstner%2C%20A.%3B%20F%26%23xE4%3Bhnrich%2C%20A.%3B%20Ketzer%2C%20J.%3B%20Fliedner%2C%20S.%20M.%20J.%3B%20Reimer%2C%20N.%3B%20Bernard%2C%20V.%3B%20Von%20Bubnoff%2C%20N.%3B%20Merz%2C%20H.%3B%20Busch%2C%20H.%3B%20Feller%2C%20A.%3B%20Gebauer%2C%20N.%20Molecularly%20Stratified%20Treatment%20Options%20in%20Primary%20Refractory%20DLBCL%5C%2FHGBL%20with%20MYC%20and%20BCL2%20or%20BCL6%20Rearrangements%20%28HGBL%2C%20NOS%20with%20MYC%5C%2FBCL6%29.%20%26lt%3Bi%26gt%3BTarg%20Oncol%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B2023%26lt%3B%5C%2Fb%26gt%3B%2C%20%26lt%3Bi%26gt%3B18%26lt%3B%5C%2Fi%26gt%3B%20%285%29%2C%20749%26%23×2013%3B765.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11523-023-00983-5%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs11523-023-00983-5%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Molecularly%20Stratified%20Treatment%20Options%20in%20Primary%20Refractory%20DLBCL%5C%2FHGBL%20with%20MYC%20and%20BCL2%20or%20BCL6%20Rearrangements%20%28HGBL%2C%20NOS%20with%20MYC%5C%2FBCL6%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanno%20M.%22%2C%22lastName%22%3A%22Witte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rg%22%2C%22lastName%22%3A%22Riedl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Axel%22%2C%22lastName%22%3A%22K%5Cu00fcnstner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anke%22%2C%22lastName%22%3A%22F%5Cu00e4hnrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julius%22%2C%22lastName%22%3A%22Ketzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%20M.%20J.%22%2C%22lastName%22%3A%22Fliedner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronica%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikolas%22%2C%22lastName%22%3A%22Von%20Bubnoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hartmut%22%2C%22lastName%22%3A%22Merz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alfred%22%2C%22lastName%22%3A%22Feller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Gebauer%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2209%5C%2F2023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs11523-023-00983-5%22%2C%22ISSN%22%3A%221776-2596%2C%201776-260X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs11523-023-00983-5%22%2C%22collections%22%3A%5B%22L242IFDH%22%2C%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222023-11-24T12%3A30%3A49Z%22%7D%7D%2C%7B%22key%22%3A%22B9TSL9WX%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Witte%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BWitte%2C%20H.%20M.%3B%20F%26%23xE4%3Bhnrich%2C%20A.%3B%20K%26%23xFC%3Bnstner%2C%20A.%3B%20Riedl%2C%20J.%3B%20Fliedner%2C%20S.%20M.%20J.%3B%20Reimer%2C%20N.%3B%20Hertel%2C%20N.%3B%20von%20Bubnoff%2C%20N.%3B%20Bernard%2C%20V.%3B%20Merz%2C%20H.%3B%20Busch%2C%20H.%3B%20Feller%2C%20A.%3B%20Gebauer%2C%20N.%20Primary%20Refractory%20Plasmablastic%20Lymphoma%3A%20A%20Precision%20Oncology%20Approach.%20%26lt%3Bi%26gt%3BFrontiers%20in%20Oncology%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B2023%26lt%3B%5C%2Fb%26gt%3B%2C%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffonc.2023.1129405%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffonc.2023.1129405%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Primary%20refractory%20plasmablastic%20lymphoma%3A%20A%20precision%20oncology%20approach%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanno%20M.%22%2C%22lastName%22%3A%22Witte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anke%22%2C%22lastName%22%3A%22F%5Cu00e4hnrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Axel%22%2C%22lastName%22%3A%22K%5Cu00fcnstner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rg%22%2C%22lastName%22%3A%22Riedl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%20M.%20J.%22%2C%22lastName%22%3A%22Fliedner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadine%22%2C%22lastName%22%3A%22Hertel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikolas%22%2C%22lastName%22%3A%22von%20Bubnoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronica%22%2C%22lastName%22%3A%22Bernard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hartmut%22%2C%22lastName%22%3A%22Merz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alfred%22%2C%22lastName%22%3A%22Feller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Gebauer%22%7D%5D%2C%22abstractNote%22%3A%22%26lt%3Bsec%26gt%3BIntroductionHematologic%20malignancies%20are%20currently%20underrepresented%20in%20multidisciplinary%20molecular-tumor-boards%20%28MTB%29.%20This%20study%20assesses%20the%20potential%20of%20precision-oncology%20in%20primary-refractory%20plasmablastic-lymphoma%20%28prPBL%29%2C%20a%20highly%20lethal%20blood%20cancer.%26lt%3B%5C%2Fsec%26gt%3B%26lt%3Bsec%26gt%3BMethodsWe%20evaluated%20clinicopathological%20and%20molecular-genetic%20data%20of%2014%20clinically%20annotated%20prPBL-patients%20from%20initial%20diagnosis.%20For%20this%20proof-of-concept%20study%2C%20we%20employed%20our%20certified%20institutional%20MTB-pipeline%20%28University-Cancer-Center-Schleswig-Holstein%2C%20UCCSH%29%20to%20annotate%20a%20comprehensive%20dataset%20within%20the%20scope%20of%20a%20virtual%20MTB-setting%2C%20ultimately%20recommending%20molecularly%20stratified%20therapies.%20Evidence-levels%20for%20MTB-recommendations%20were%20defined%20in%20accordance%20with%20the%20NCT%5C%2FDKTK%20and%20ESCAT%20criteria.%26lt%3B%5C%2Fsec%26gt%3B%26lt%3Bsec%26gt%3BResultsMedian%20age%20in%20the%20cohort%20was%2076.5%20years%20%28range%2056-91%29%2C%2078.6%25%20of%20patients%20were%20male%2C%2050%25%20were%20HIV-positive%20and%20clinical%20outcome%20was%20dismal.%20Comprehensive%20genomic%5C%2Ftranscriptomic%20analysis%20revealed%20potential%20recommendations%20of%20a%20molecularly%20stratified%20treatment%20option%20with%20evidence-levels%20according%20to%20NCT%5C%2FDKTK%20of%20at%20least%20m2B%5C%2FESCAT%20of%20at%20least%20IIIA%20were%20detected%20for%20all%2014%20prPBL-cases.%20In%20addition%2C%20immunohistochemical-assessment%20%28CD19%5C%2FCD30%5C%2FCD38%5C%2FCD79B%29%20revealed%20targeted%20treatment-recommendations%20in%20all%2014%20cases.%20Genetic%20alterations%20were%20classified%20by%20treatment-baskets%20proposed%20by%20Horak%20et%20al.%20Hereby%2C%20we%20identified%20tyrosine-kinases%20%28TK%3B%20n%3D4%29%2C%20PI3K-MTOR-AKT-pathway%20%28PAM%3B%20n%3D3%29%2C%20cell-cycle-alterations%20%28CC%3B%20n%3D2%29%2C%20RAF-MEK-ERK-cascade%20%28RME%3B%20n%3D2%29%2C%20immune-evasion%20%28IE%3B%20n%3D2%29%2C%20B-cell-targets%20%28BCT%3B%20n%3D25%29%20and%20others%20%28OTH%3B%20n%3D4%29%20for%20targeted%20treatment-recommendations.%20The%20minimum%20requirement%20for%20consideration%20of%20a%20drug%20within%20the%20scope%20of%20the%20study%20was%20FDA-fast-track%20development.%26lt%3B%5C%2Fsec%26gt%3B%26lt%3Bsec%26gt%3BDiscussionThe%20presented%20proof-of-concept%20study%20demonstrates%20the%20clinical%20potential%20of%20precision-oncology%2C%20even%20in%20prPBL-patients.%20Due%20to%20the%20aggressive%20course%20of%20the%20disease%2C%20there%20is%20an%20urgent%20medical-need%20for%20personalized%20treatment%20approaches%2C%20and%20this%20population%20should%20be%20considered%20for%20MTB%20inclusion%20at%20the%20earliest%20time.%26lt%3B%5C%2Fsec%26gt%3B%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffonc.2023.1129405%22%2C%22ISSN%22%3A%222234-943X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffonc.2023.1129405%22%2C%22collections%22%3A%5B%22L242IFDH%22%2C%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222023-02-27T13%3A08%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22735SCDJF%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bastian%20et%20al.%22%2C%22parsedDate%22%3A%222022-04-09%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BBastian%2C%20L.%3B%20Hartmann%2C%20A.%20M.%3B%20Beder%2C%20T.%3B%20H%26%23xE4%3Bnzelmann%2C%20S.%3B%20K%26%23xE4%3Bssens%2C%20J.%3B%20Bultmann%2C%20M.%3B%20Hoeppner%2C%20M.%20P.%3B%20Franzenburg%2C%20S.%3B%20Wittig%2C%20M.%3B%20Franke%2C%20A.%3B%20Nagel%2C%20I.%3B%20Spielmann%2C%20M.%3B%20Reimer%2C%20N.%3B%20Busch%2C%20H.%3B%20Schwartz%2C%20S.%3B%20Steffen%2C%20B.%3B%20Viardot%2C%20A.%3B%20D%26%23xF6%3Bhner%2C%20K.%3B%20Kondakci%2C%20M.%3B%20Wulf%2C%20G.%3B%20Wendelin%2C%20K.%3B%20Renzelmann%2C%20A.%3B%20Kiani%2C%20A.%3B%20Trautmann%2C%20H.%3B%20Neumann%2C%20M.%3B%20G%26%23xF6%3Bkbuget%2C%20N.%3B%20Br%26%23xFC%3Bggemann%2C%20M.%3B%20Baldus%2C%20C.%20D.%20UBTF%3A%3AATXN7L3%20Gene%20Fusion%20Defines%20Novel%20B%20Cell%20Precursor%20ALL%20Subtype%20with%20CDX2%20Expression%20and%20Need%20for%20Intensified%20Treatment.%20%26lt%3Bi%26gt%3BLeukemia%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B2022%26lt%3B%5C%2Fb%26gt%3B.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41375-022-01557-6%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41375-022-01557-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22UBTF%3A%3AATXN7L3%20gene%20fusion%20defines%20novel%20B%20cell%20precursor%20ALL%20subtype%20with%20CDX2%20expression%20and%20need%20for%20intensified%20treatment%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenz%22%2C%22lastName%22%3A%22Bastian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alina%20M.%22%2C%22lastName%22%3A%22Hartmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Beder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%22%2C%22lastName%22%3A%22H%5Cu00e4nzelmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22K%5Cu00e4ssens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miriam%22%2C%22lastName%22%3A%22Bultmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%20P.%22%2C%22lastName%22%3A%22Hoeppner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%5Cu00f6ren%22%2C%22lastName%22%3A%22Franzenburg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Wittig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andre%22%2C%22lastName%22%3A%22Franke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Inga%22%2C%22lastName%22%3A%22Nagel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Malte%22%2C%22lastName%22%3A%22Spielmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Schwartz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bj%5Cu00f6rn%22%2C%22lastName%22%3A%22Steffen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Viardot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Konstanze%22%2C%22lastName%22%3A%22D%5Cu00f6hner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mustafa%22%2C%22lastName%22%3A%22Kondakci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerald%22%2C%22lastName%22%3A%22Wulf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Knut%22%2C%22lastName%22%3A%22Wendelin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Renzelmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kiani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Trautmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Neumann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22G%5Cu00f6kbuget%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monika%22%2C%22lastName%22%3A%22Br%5Cu00fcggemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%20D.%22%2C%22lastName%22%3A%22Baldus%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022-04-09%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41375-022-01557-6%22%2C%22ISSN%22%3A%220887-6924%2C%201476-5551%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41375-022-01557-6%22%2C%22collections%22%3A%5B%22L242IFDH%22%2C%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222022-04-12T11%3A32%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22G45TDZQW%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Unberath%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BUnberath%2C%20P.%3B%20Mahlmeister%2C%20L.%3B%20Reimer%2C%20N.%3B%20Busch%2C%20H.%3B%20Boerries%2C%20M.%3B%20Christoph%2C%20J.%20Searching%20of%20Clinical%20Trials%20Made%20Easier%20in%20CBioPortal%20Using%20Patients%26%23×2019%3B%20Genetic%20and%20Clinical%20Profiles.%20%26lt%3Bi%26gt%3BAppl%20Clin%20Inform%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B2022%26lt%3B%5C%2Fb%26gt%3B%2C%20%26lt%3Bi%26gt%3B13%26lt%3B%5C%2Fi%26gt%3B%20%2802%29%2C%20363%26%23×2013%3B369.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1055%5C%2Fs-0042-1743560%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1055%5C%2Fs-0042-1743560%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Searching%20of%20Clinical%20Trials%20Made%20Easier%20in%20cBioPortal%20Using%20Patients%27%20Genetic%20and%20Clinical%20Profiles%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Unberath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Mahlmeister%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Boerries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Christoph%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Background%5Cu2003Molecular%20tumor%20boards%20%28MTBs%29%20cope%20with%20the%20complexity%20of%20an%20increased%20usage%20of%20genome%20sequencing%20data%20in%20cancer%20treatment.%20As%20for%20most%20of%20these%20patients%2C%20guideline-based%20therapy%20options%20are%20exhausted%2C%20finding%20matching%20clinical%20trials%20is%20crucial.%20This%20search%20process%20is%20often%20performed%20manually%20and%20therefore%20time%20consuming%20and%20complex%20due%20to%20the%20heterogeneous%20and%20challenging%20dataset.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Objectives%5Cu2003In%20this%20study%2C%20a%20prototype%20for%20a%20search%20tool%20was%20developed%20to%20demonstrate%20how%20cBioPortal%20as%20a%20clinical%20and%20genomic%20patient%20data%20source%20can%20be%20integrated%20with%20ClinicalTrials.gov%2C%20a%20database%20of%20clinical%20studies%20to%20simplify%20the%20search%20for%20trials%20based%20on%20genetic%20and%20clinical%20data%20of%20a%20patient.%20The%20design%20of%20this%20tool%20should%20rest%20on%20the%20specific%20needs%20of%20MTB%20participants%20and%20the%20architecture%20of%20the%20integration%20should%20be%20as%20lightweight%20as%20possible%20and%20should%20not%20require%20manual%20curation%20of%20trial%20data%20in%20advance%20with%20the%20goal%20of%20quickly%20and%20easily%20finding%20a%20matching%20study.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cu2003Based%20on%20a%20requirements%20analysis%2C%20interviewing%20MTB%20experts%2C%20a%20prototype%20was%20developed.%20It%20was%20further%20refined%20using%20a%20user-centered%20development%20process%20with%20multiple%20feedback%20loops.%20Finally%2C%20the%20usability%20of%20the%20application%20was%20evaluated%20with%20user%20interviews%20including%20the%20thinking-aloud%20protocol%20and%20the%20system%20usability%20scale%20%28SUS%29%20questionnaire.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cu2003The%20integration%20of%20ClinicalTrials.gov%20in%20cBioPortal%20is%20achieved%20by%20a%20new%20tab%20in%20the%20patient%20view%20where%20the%20genomic%20profile%20for%20the%20search%20is%20prefilled%20and%20additional%20parameters%20can%20be%20adjusted.%20These%20parameters%20are%20then%20used%20to%20query%20the%20application%20programming%20interface%20%28API%29%20of%20ClinicalTrials.gov.%20The%20returned%20search%20results%20subsequently%20are%20ranked%20and%20presented%20to%20the%20user.%20The%20evaluation%20of%20the%20application%20resulted%20in%20an%20SUS%20score%20of%2083.5.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%5Cu2003This%20work%20demonstrates%20the%20integration%20of%20cBioPortal%20with%20ClinicalTrials.gov%20to%20use%20clinical%20and%20genomic%20patient%20data%20to%20search%20for%20appropriate%20trials%20within%20an%20MTB.%22%2C%22date%22%3A%2203%5C%2F2022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1055%5C%2Fs-0042-1743560%22%2C%22ISSN%22%3A%221869-0327%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.thieme-connect.de%5C%2FDOI%5C%2FDOI%3F10.1055%5C%2Fs-0042-1743560%22%2C%22collections%22%3A%5B%22L242IFDH%22%2C%229VVLWC3C%22%2C%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222022-03-31T12%3A50%3A50Z%22%7D%7D%2C%7B%22key%22%3A%223LHYRISN%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Reimer%20et%20al.%22%2C%22parsedDate%22%3A%222021-11-18%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BReimer%2C%20N.%3B%20Unberath%2C%20P.%3B%20Busch%2C%20H.%3B%20B%26%23xF6%3Brries%2C%20M.%3B%20Metzger%2C%20P.%3B%20Ustjanzew%2C%20A.%3B%20Renner%2C%20C.%3B%20Prokosch%2C%20H.-U.%3B%20Christoph%2C%20J.%20Challenges%20and%20Experiences%20Extending%20the%20CBioPortal%20for%20Cancer%20Genomics%20to%20a%20Molecular%20Tumor%20Board%20Platform.%20In%20%26lt%3Bi%26gt%3BStudies%20in%20Health%20Technology%20and%20Informatics%26lt%3B%5C%2Fi%26gt%3B%3B%20Delgado%2C%20J.%2C%20Benis%2C%20A.%2C%20De%20Toledo%2C%20P.%2C%20Gallos%2C%20P.%2C%20Giacomini%2C%20M.%2C%20Mart%26%23xED%3Bnez-Garc%26%23xED%3Ba%2C%20A.%2C%20Salvi%2C%20D.%2C%20Eds.%3B%20IOS%20Press%2C%202021.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3233%5C%2FSHTI210833.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22bookSection%22%2C%22title%22%3A%22Challenges%20and%20Experiences%20Extending%20the%20cBioPortal%20for%20Cancer%20Genomics%20to%20a%20Molecular%20Tumor%20Board%20Platform%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Jaime%22%2C%22lastName%22%3A%22Delgado%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Arriel%22%2C%22lastName%22%3A%22Benis%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Paula%22%2C%22lastName%22%3A%22De%20Toledo%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Parisis%22%2C%22lastName%22%3A%22Gallos%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Mauro%22%2C%22lastName%22%3A%22Giacomini%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Alicia%22%2C%22lastName%22%3A%22Mart%5Cu00ednez-Garc%5Cu00eda%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Dario%22%2C%22lastName%22%3A%22Salvi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Unberath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22B%5Cu00f6rries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Metzger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arsenij%22%2C%22lastName%22%3A%22Ustjanzew%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22Renner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22Prokosch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Christoph%22%7D%5D%2C%22abstractNote%22%3A%22In%20Molecular%20Tumor%20Boards%20%28MTBs%29%2C%20therapy%20recommendations%20for%20cancer%20patients%20are%20discussed.%20To%20aid%20decision-making%20based%20on%20the%20patient%5Cu2019s%20molecular%20profile%2C%20the%20research%20platform%20cBioPortal%20was%20extended%20based%20on%20users%5Cu2019%20requirements.%20Additionally%2C%20a%20comprehensive%20dockerized%20workflow%20was%20developed%20to%20support%20the%20deployment%20of%20cBioPortal%20and%20connected%20services.%20In%20this%20work%2C%20we%20present%20the%20challenges%20and%20experiences%20of%20nearly%20two%20years%20of%20implementing%20and%20deploying%20an%20MTB%20platform%20based%20on%20cBioPortal%20and%20compare%20those%20to%20findings%20of%20a%20previous%20study.%22%2C%22bookTitle%22%3A%22Studies%20in%20Health%20Technology%20and%20Informatics%22%2C%22date%22%3A%222021-11-18%22%2C%22language%22%3A%22%22%2C%22ISBN%22%3A%22978-1-64368-236-5%20978-1-64368-237-2%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Febooks.iospress.nl%5C%2Fdoi%5C%2F10.3233%5C%2FSHTI210833%22%2C%22collections%22%3A%5B%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222023-11-24T13%3A56%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22CAGRVLS5%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Reimer%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-27%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BReimer%2C%20N.%3B%20Unberath%2C%20P.%3B%20Busch%2C%20H.%3B%20Ingenerf%2C%20J.%20FhirSpark%20%26%23×2013%3B%20Implementing%20a%20Mediation%20Layer%20to%20Bring%20FHIR%20to%20the%20CBioPortal%20for%20Cancer%20Genomics.%20In%20%26lt%3Bi%26gt%3BStudies%20in%20Health%20Technology%20and%20Informatics%26lt%3B%5C%2Fi%26gt%3B%3B%20Mantas%2C%20J.%2C%20Stoicu-Tivadar%2C%20L.%2C%20Chronaki%2C%20C.%2C%20Hasman%2C%20A.%2C%20Weber%2C%20P.%2C%20Gallos%2C%20P.%2C%20Cri%26%23x15F%3Ban-Vida%2C%20M.%2C%20Zoulias%2C%20E.%2C%20Chirila%2C%20O.%20S.%2C%20Eds.%3B%20IOS%20Press%2C%202021.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3233%5C%2FSHTI210169.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22bookSection%22%2C%22title%22%3A%22FhirSpark%20%5Cu2013%20Implementing%20a%20Mediation%20Layer%20to%20Bring%20FHIR%20to%20the%20cBioPortal%20for%20Cancer%20Genomics%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Mantas%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22L%5Cu0103cr%5Cu0103mioara%22%2C%22lastName%22%3A%22Stoicu-Tivadar%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Chronaki%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Arie%22%2C%22lastName%22%3A%22Hasman%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Weber%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Parisis%22%2C%22lastName%22%3A%22Gallos%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Mihaela%22%2C%22lastName%22%3A%22Cri%5Cu015fan-Vida%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Emmanouil%22%2C%22lastName%22%3A%22Zoulias%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Oana%20Sorina%22%2C%22lastName%22%3A%22Chirila%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Unberath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josef%22%2C%22lastName%22%3A%22Ingenerf%22%7D%5D%2C%22abstractNote%22%3A%22cBioPortal%20is%20a%20commonly%20used%20data%20warehousing%20solution%20for%20genomic%20cancer%20studies.%20The%20software%20is%20being%20extended%20for%20patient%20care%20application%20in%20a%20molecular%20tumor%20board%20by%20the%20MIRACUM%20consortium%20within%20the%20Medical%20Informatics%20Initiative%20Germany.%20A%20key%20feature%20for%20this%20use%20case%20is%20the%20ability%20to%20enter%20therapy%20recommendations%20for%20individual%20patients%2C%20which%20requires%20interoperability%20with%20the%20hospital%20information%20system.%20A%20RESTful%20interface%20between%20cBioPortal%20and%20an%20external%20mediation%20layer%20was%20selected%20from%20the%20different%20implementation%20options.%20It%20achieves%20interoperability%20by%20using%20a%20FHIR%20capable%20server%20to%20store%20data%20and%20applying%20the%20HL7%20FHIR%20Genomics%20Reporting%20implementation%20guide.%20For%20systems%20not%20supporting%20the%20FHIR%20standard%2C%20the%20well-established%20HL7%20Version%202%20standard%20is%20available%20as%20a%20fallback%20export%20format.%22%2C%22bookTitle%22%3A%22Studies%20in%20Health%20Technology%20and%20Informatics%22%2C%22date%22%3A%222021-05-27%22%2C%22language%22%3A%22%22%2C%22ISBN%22%3A%22978-1-64368-184-9%20978-1-64368-185-6%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Febooks.iospress.nl%5C%2Fdoi%5C%2F10.3233%5C%2FSHTI210169%22%2C%22collections%22%3A%5B%22L242IFDH%22%2C%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222021-11-19T14%3A12%3A00Z%22%7D%7D%2C%7B%22key%22%3A%226EFXXGQA%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Reimer%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-24%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BReimer%2C%20N.%3B%20Ulrich%2C%20H.%3B%20Busch%2C%20H.%3B%20Kock-Schoppenhauer%2C%20A.-K.%3B%20Ingenerf%2C%20J.%20OpenEHR%20Mapper%20%26%23×2013%3B%20A%20Tool%20to%20Fuse%20Clinical%20and%20Genomic%20Data%20Using%20the%20OpenEHR%20Standard.%20In%20%26lt%3Bi%26gt%3BStudies%20in%20Health%20Technology%20and%20Informatics%26lt%3B%5C%2Fi%26gt%3B%3B%20R%26%23xF6%3Bhrig%2C%20R.%2C%20Bei%26%23xDF%3Bbarth%2C%20T.%2C%20Brannath%2C%20W.%2C%20Prokosch%2C%20H.-U.%2C%20Schmidtmann%2C%20I.%2C%20Stolpe%2C%20S.%2C%20Zapf%2C%20A.%2C%20Eds.%3B%20IOS%20Press%2C%202021.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3233%5C%2FSHTI210055.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22bookSection%22%2C%22title%22%3A%22openEHR%20Mapper%20%5Cu2013%20A%20Tool%20to%20Fuse%20Clinical%20and%20Genomic%20Data%20Using%20the%20openEHR%20Standard%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Rainer%22%2C%22lastName%22%3A%22R%5Cu00f6hrig%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Tim%22%2C%22lastName%22%3A%22Bei%5Cu00dfbarth%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Werner%22%2C%22lastName%22%3A%22Brannath%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22Prokosch%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Irene%22%2C%22lastName%22%3A%22Schmidtmann%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Stolpe%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Antonia%22%2C%22lastName%22%3A%22Zapf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannes%22%2C%22lastName%22%3A%22Ulrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ann-Kristin%22%2C%22lastName%22%3A%22Kock-Schoppenhauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josef%22%2C%22lastName%22%3A%22Ingenerf%22%7D%5D%2C%22abstractNote%22%3A%22Precision%20medicine%20is%20an%20emerging%20and%20important%20field%20for%20health%20care.%20Molecular%20tumor%20boards%20use%20a%20combination%20of%20clinical%20and%20molecular%20data%2C%20such%20as%20somatic%20tumor%20mutations%20to%20decide%20on%20personalized%20therapies%20for%20patients%20who%20have%20run%20out%20of%20standard%20treatment%20options.%20Personalized%20treatment%20decisions%20require%20clinical%20data%20from%20the%20hospital%20information%20system%20and%20mutation%20data%20to%20be%20accessible%20in%20a%20structured%20way.%20Here%20we%20introduce%20an%20open%20data%20platform%20to%20meet%20these%20requirements.%20We%20use%20the%20openEHR%20standard%20to%20create%20an%20expert-curated%20data%20model%20that%20is%20stored%20in%20a%20vendor-neutral%20format.%20Clinical%20and%20molecular%20patient%20data%20is%20integrated%20into%20cBioPortal%2C%20a%20warehousing%20solution%20for%20cancer%20genomic%20studies%20that%20is%20extended%20for%20use%20in%20clinical%20routine%20for%20molecular%20tumor%20boards.%20For%20data%20integration%2C%20we%20developed%20openEHR%20Mapper%2C%20a%20tool%20that%20allows%20to%20%28i%29%20process%20input%20data%2C%20%28ii%29%20communicate%20with%20the%20openEHR%20repository%2C%20and%20%28iii%29%20export%20the%20data%20to%20cBioPortal.%20We%20benchmarked%20the%20mapper%20performance%20using%20XML%20and%20JSON%20as%20serialization%20format%20and%20added%20caching%20capabilities%20as%20well%20as%20multi-threading%20to%20the%20openEHR%20Mapper.%22%2C%22bookTitle%22%3A%22Studies%20in%20Health%20Technology%20and%20Informatics%22%2C%22date%22%3A%222021-05-24%22%2C%22language%22%3A%22%22%2C%22ISBN%22%3A%22978-1-64368-176-4%20978-1-64368-177-1%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Febooks.iospress.nl%5C%2Fdoi%5C%2F10.3233%5C%2FSHTI210055%22%2C%22collections%22%3A%5B%22L242IFDH%22%2C%22XCWS34QW%22%2C%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222021-05-29T08%3A46%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22YDZUCQM9%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kock-Schoppenhauer%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BKock-Schoppenhauer%2C%20A.-K.%3B%20Schreiweis%2C%20B.%3B%20Ulrich%2C%20H.%3B%20Reimer%2C%20N.%3B%20Wiedekopf%2C%20J.%3B%20Kinast%2C%20B.%3B%20Busch%2C%20H.%3B%20Bergh%2C%20B.%3B%20Ingenerf%2C%20J.%20Medical%20Data%20Engineering%20%26%23×2013%3B%20Theory%20and%20Practice.%20In%20%26lt%3Bi%26gt%3BAdvances%20in%20Model%20and%20Data%20Engineering%20in%20the%20Digitalization%20Era%26lt%3B%5C%2Fi%26gt%3B%3B%20Bellatreche%2C%20L.%2C%20Chernishev%2C%20G.%2C%20Corral%2C%20A.%2C%20Ouchani%2C%20S.%2C%20Vain%2C%20J.%2C%20Eds.%3B%20Springer%20International%20Publishing%3A%20Cham%2C%202021%3B%20Vol.%201481%2C%20pp%20269%26%23×2013%3B284.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2F978-3-030-87657-9_21.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22bookSection%22%2C%22title%22%3A%22Medical%20Data%20Engineering%20%5Cu2013%20Theory%20and%20Practice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Ladjel%22%2C%22lastName%22%3A%22Bellatreche%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22George%22%2C%22lastName%22%3A%22Chernishev%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Antonio%22%2C%22lastName%22%3A%22Corral%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Samir%22%2C%22lastName%22%3A%22Ouchani%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22J%5Cu00fcri%22%2C%22lastName%22%3A%22Vain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ann-Kristin%22%2C%22lastName%22%3A%22Kock-Schoppenhauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bj%5Cu00f6rn%22%2C%22lastName%22%3A%22Schreiweis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannes%22%2C%22lastName%22%3A%22Ulrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joshua%22%2C%22lastName%22%3A%22Wiedekopf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Kinast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hauke%22%2C%22lastName%22%3A%22Busch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bj%5Cu00f6rn%22%2C%22lastName%22%3A%22Bergh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josef%22%2C%22lastName%22%3A%22Ingenerf%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22bookTitle%22%3A%22Advances%20in%20Model%20and%20Data%20Engineering%20in%20the%20Digitalization%20Era%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22en%22%2C%22ISBN%22%3A%22978-3-030-87656-2%20978-3-030-87657-9%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2F978-3-030-87657-9_21%22%2C%22collections%22%3A%5B%22XCWS34QW%22%2C%229VVLWC3C%22%2C%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222021-10-08T21%3A09%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22AZ5CDAGE%22%2C%22library%22%3A%7B%22id%22%3A7575694%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Groppe%20and%20Reimer%22%2C%22parsedDate%22%3A%222019%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%20style%3D%26quot%3Bclear%3A%20left%3B%20%26quot%3B%26gt%3B%5Cn%20%20%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-left-margin%26quot%3B%20style%3D%26quot%3Bfloat%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%26quot%3B%26gt%3B%281%29%26lt%3B%5C%2Fdiv%26gt%3B%26lt%3Bdiv%20class%3D%26quot%3Bcsl-right-inline%26quot%3B%20style%3D%26quot%3Bmargin%3A%200%20.4em%200%201.5em%3B%26quot%3B%26gt%3BGroppe%2C%20S.%3B%20Reimer%2C%20N.%20Code%20Generation%20for%20Big%20Data%20Processing%20in%20the%20Web%20Using%20WebAssembly.%20%26lt%3Bi%26gt%3BOpen%20Journal%20of%20Cloud%20Computing%20%28OJCC%29%26lt%3B%5C%2Fi%26gt%3B%20%26lt%3Bb%26gt%3B2019%26lt%3B%5C%2Fb%26gt%3B%2C%20%26lt%3Bi%26gt%3B6%26lt%3B%5C%2Fi%26gt%3B%20%281%29%2C%201%26%23×2013%3B15.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%20%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Code%20Generation%20for%20Big%20Data%20Processing%20in%20the%20Web%20using%20WebAssembly%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sven%22%2C%22lastName%22%3A%22Groppe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Reimer%22%7D%5D%2C%22abstractNote%22%3A%22Traditional%20clusters%20for%20cloud%20computing%20are%20quite%20hard%20to%20configure%20and%20setup%2C%20and%20the%20number%20of%20cluster%20nodes%20is%20limited%20by%20the%20available%20hardware%20in%20the%20cluster.%20We%20hence%20envision%20the%20concept%20of%20a%20Browser%20Cloud%3A%20One%20just%20has%20to%20visit%20with%20his%5C%2Fher%20web%20browser%20a%20certain%20webpage%20in%20order%20to%20connect%20his%5C%2Fher%20computer%20to%20the%20Browser%20Cloud.%20In%20this%20way%20the%20setup%20of%20the%20Browser%20Cloud%20is%20much%20easier%20than%20those%20of%20traditional%20clouds.%20Furthermore%2C%20the%20Browser%20Cloud%20has%20a%20much%20larger%20number%20of%20potential%20nodes%2C%20as%20any%20computer%20running%20a%20browser%20may%20connect%20to%20and%20be%20integrated%20in%20the%20Browser%20Cloud.%20New%20challenges%20arise%20when%20setting%20up%20a%20cloud%20by%20web%20browsers%3A%20Data%20is%20processed%20within%20the%20browser%2C%20which%20requires%20to%20use%20the%20technologies%20offered%20by%20the%20browser%20for%20this%20purpose.%20The%20typically%20used%20JavaScript%20runtime%20environment%20may%20be%20too%20slow%2C%20because%20JavaScript%20is%20an%20interpreted%20language.%20Hence%20we%20investigate%20the%20possibilities%20for%20computing%20the%20work-intensive%20part%20of%20the%20query%20processing%20inside%20a%20virtual%20machine%20of%20the%20web%20browser.%20The%20technology%20WebAssemby%20for%20virtual%20machines%20is%20recently%20supported%20by%20all%20major%20browsers%20and%20promises%20high%20speedups%20in%20comparison%20with%20JavaScript.%20Recent%20approaches%20to%20efficient%20Big%20Data%20processing%20generate%20code%20for%20the%20data%20processing%20steps%20of%20queries.%20To%20run%20the%20generated%20code%20in%20a%20WebAssembly%20virtual%20machine%2C%20an%20online%20compiler%20is%20needed%20to%20generate%20the%20WebAssembly%20bytecode%20from%20the%20generated%20code.%20Hence%20our%20main%20contribution%20is%20an%20online%20compiler%20to%20WebAssembly%20bytecode%20especially%20developed%20to%20run%20in%20the%20web%20browser%20and%20for%20Big%20Data%20processing%20based%20on%20code%20generation%20of%20the%20processing%20steps.%20In%20our%20experiments%2C%20the%20runtimes%20of%20Big%20Data%20processing%20using%20JavaScript%20is%20compared%20with%20running%20WebAssembly%20technologies%20in%20the%20major%20web%20browsers.%22%2C%22date%22%3A%222019%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%222199-1987%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fnbn-resolving.de%5C%2Furn%3Anbn%3Ade%3A101%3A1-2020011918330924188531%22%2C%22collections%22%3A%5B%22L242IFDH%22%2C%22HKKZERLJ%22%5D%2C%22dateModified%22%3A%222021-03-18T12%3A34%3A24Z%22%7D%7D%5D%7D
(1)
Bossenz, J.; Manuilova, I.; Weise, A. B.; Schulze, S.; Hiemer, S.; Eszlinger, M.; Boerries, M.; Busch, H.; Boehm, D.; Unberath, P.; Reimer, N.; Strantz, C.; Christoph, J. Prototypical Visualization of Patient Similarities in CBioPortal to Enhance Decision-Making in Molecular Tumor Boards. In Studies in Health Technology and Informatics; Andrikopoulou, E., Gallos, P., Arvanitis, T. N., Austin, R., Benis, A., Cornet, R., Chatzistergos, P., Dejaco, A., Dusseljee-Peute, L., Mohasseb, A., Natsiavas, P., Nakkas, H., Scott, P., Eds.; IOS Press, 2025. https://doi.org/10.3233/SHTI250385.
(1)
Boehm, D.; Reimer, N.; Christoph, J.; Scheiter, A.; Unberath, P. Building a Knowledge Base for Variant Annotation Using Therapy Recommendations in CBioPortal. In Studies in Health Technology and Informatics; Andrikopoulou, E., Gallos, P., Arvanitis, T. N., Austin, R., Benis, A., Cornet, R., Chatzistergos, P., Dejaco, A., Dusseljee-Peute, L., Mohasseb, A., Natsiavas, P., Nakkas, H., Scott, P., Eds.; IOS Press, 2025. https://doi.org/10.3233/SHTI250281.
(1)
Schladetzky, J.; Reimer, N.; Nicolaus, H.; Busch, H.; Schreiweis, B.; Kock-Schoppenhauer, A.-K. Integration of Oncological Data into OpenEHR: A Path Towards Improved Cancer Care and Research. In Studies in Health Technology and Informatics; Mantas, J., Hasman, A., Demiris, G., Saranto, K., Marschollek, M., Arvanitis, T. N., Ognjanović, I., Benis, A., Gallos, P., Zoulias, E., Andrikopoulou, E., Eds.; IOS Press, 2024. https://doi.org/10.3233/SHTI240655.
(1)
Renner, C.; Reimer, N.; Christoph, J.; Busch, H.; Metzger, P.; Boerries, M.; Ustjanzew, A.; Boehm, D.; Unberath, P. Extending CBioPortal for Therapy Recommendation Documentation in Molecular Tumor Boards: Development and Usability Study. JMIR Med Inform 2023, 11, e50017. https://doi.org/10.2196/50017.
(1)
Metzger, P.; Hess, M. E.; Blaumeiser, A.; Pauli, T.; Schipperges, V.; Mertes, R.; Christoph, J.; Unberath, P.; Reimer, N.; Scheible, R.; Illert, A. L.; Busch, H.; Andrieux, G.; Boerries, M. MIRACUM-Pipe: An Adaptable Pipeline for Next-Generation Sequencing Analysis, Reporting, and Visualization for Clinical Decision Making. Cancers 2023, 15 (13), 3456. https://doi.org/10.3390/cancers15133456.
(1)
Witte, H. M.; Riedl, J.; Künstner, A.; Fähnrich, A.; Ketzer, J.; Fliedner, S. M. J.; Reimer, N.; Bernard, V.; Von Bubnoff, N.; Merz, H.; Busch, H.; Feller, A.; Gebauer, N. Molecularly Stratified Treatment Options in Primary Refractory DLBCL/HGBL with MYC and BCL2 or BCL6 Rearrangements (HGBL, NOS with MYC/BCL6). Targ Oncol 2023, 18 (5), 749–765. https://doi.org/10.1007/s11523-023-00983-5.
(1)
Witte, H. M.; Fähnrich, A.; Künstner, A.; Riedl, J.; Fliedner, S. M. J.; Reimer, N.; Hertel, N.; von Bubnoff, N.; Bernard, V.; Merz, H.; Busch, H.; Feller, A.; Gebauer, N. Primary Refractory Plasmablastic Lymphoma: A Precision Oncology Approach. Frontiers in Oncology 2023, 13. https://doi.org/10.3389/fonc.2023.1129405.
(1)
Bastian, L.; Hartmann, A. M.; Beder, T.; Hänzelmann, S.; Kässens, J.; Bultmann, M.; Hoeppner, M. P.; Franzenburg, S.; Wittig, M.; Franke, A.; Nagel, I.; Spielmann, M.; Reimer, N.; Busch, H.; Schwartz, S.; Steffen, B.; Viardot, A.; Döhner, K.; Kondakci, M.; Wulf, G.; Wendelin, K.; Renzelmann, A.; Kiani, A.; Trautmann, H.; Neumann, M.; Gökbuget, N.; Brüggemann, M.; Baldus, C. D. UBTF::ATXN7L3 Gene Fusion Defines Novel B Cell Precursor ALL Subtype with CDX2 Expression and Need for Intensified Treatment. Leukemia 2022. https://doi.org/10.1038/s41375-022-01557-6.
(1)
Unberath, P.; Mahlmeister, L.; Reimer, N.; Busch, H.; Boerries, M.; Christoph, J. Searching of Clinical Trials Made Easier in CBioPortal Using Patients’ Genetic and Clinical Profiles. Appl Clin Inform 2022, 13 (02), 363–369. https://doi.org/10.1055/s-0042-1743560.
(1)
Reimer, N.; Unberath, P.; Busch, H.; Börries, M.; Metzger, P.; Ustjanzew, A.; Renner, C.; Prokosch, H.-U.; Christoph, J. Challenges and Experiences Extending the CBioPortal for Cancer Genomics to a Molecular Tumor Board Platform. In Studies in Health Technology and Informatics; Delgado, J., Benis, A., De Toledo, P., Gallos, P., Giacomini, M., Martínez-García, A., Salvi, D., Eds.; IOS Press, 2021. https://doi.org/10.3233/SHTI210833.
(1)
Reimer, N.; Unberath, P.; Busch, H.; Ingenerf, J. FhirSpark – Implementing a Mediation Layer to Bring FHIR to the CBioPortal for Cancer Genomics. In Studies in Health Technology and Informatics; Mantas, J., Stoicu-Tivadar, L., Chronaki, C., Hasman, A., Weber, P., Gallos, P., Crişan-Vida, M., Zoulias, E., Chirila, O. S., Eds.; IOS Press, 2021. https://doi.org/10.3233/SHTI210169.
(1)
Reimer, N.; Ulrich, H.; Busch, H.; Kock-Schoppenhauer, A.-K.; Ingenerf, J. OpenEHR Mapper – A Tool to Fuse Clinical and Genomic Data Using the OpenEHR Standard. In Studies in Health Technology and Informatics; Röhrig, R., Beißbarth, T., Brannath, W., Prokosch, H.-U., Schmidtmann, I., Stolpe, S., Zapf, A., Eds.; IOS Press, 2021. https://doi.org/10.3233/SHTI210055.
(1)
Kock-Schoppenhauer, A.-K.; Schreiweis, B.; Ulrich, H.; Reimer, N.; Wiedekopf, J.; Kinast, B.; Busch, H.; Bergh, B.; Ingenerf, J. Medical Data Engineering – Theory and Practice. In Advances in Model and Data Engineering in the Digitalization Era; Bellatreche, L., Chernishev, G., Corral, A., Ouchani, S., Vain, J., Eds.; Springer International Publishing: Cham, 2021; Vol. 1481, pp 269–284. https://doi.org/10.1007/978-3-030-87657-9_21.
(1)
Groppe, S.; Reimer, N. Code Generation for Big Data Processing in the Web Using WebAssembly. Open Journal of Cloud Computing (OJCC) 2019, 6 (1), 1–15.