Position and Responsibilities
Scientific Profile
Publications
Position and Responsibilities
- NGS Data Analysis, Genomics, Transcriptomics, Bioinformatics, Algorithms, Data Science, Systems Medicine
Scientific Profile
- Inken Wohlers graduated in Bioinformatics from FU Berlin and did her PhD in Algorithmic Computational Biology at the Dutch national research institute for math and computer science (CWI) in Amsterdam, the Netherlands.
She worked many years as Bioinformatician at university hospitals in Berlin, Essen and Lübeck on research projects involving analysis of large scale *omics data. She was lead Bioinormatician constructing the Egyptian genome ressource published in 2020.
Current projects
- ONT data analysis (with Institute of Neurogenetics and Institute for Cardiogenetics)
- North-East African Mitochondrial haplogroups (with Genetics Division of LIED)
- Ancient introgression (with Ancient DNA Lab and Genetics & Bioinformatics at CAU Kiel)
- Prediction of effects of synonymous disease variants (with Institute for Cardiogenetics)
Publications
- M. Munz, M. Khodaygani, Z. Aherrahrou, H. Busch and I. Wohlers. In silico candidate variant and gene identification using inbred mouse strains. PeerJ 2021
- D. Prokopenko, S. L. Morgan, K. Mullin, O. Hofmann, B. Chapman, R. Kirchner, S. Amberkar, I. Wohlers, C. Lange, W. Hide, L. Bertram and R. E. Tanzi. Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants in loci related to synaptic function and neuronal development. Alzheimers. Dement. 2021
- M. Ohms, C. Ferreira, H. Busch, I. Wohlers, A. C. Guerra de Souza, R. Silvestre and T. Laskay. Enhanced glycolysis is required for antileishmanial functions of neutrophils upon infection with Leishmania donovani. Accepted at Front. Immunol. 2021
- M. Munz, I. Wohlers, E. Simon, T. Reinberger, H. Busch, A. S. Schaefer, J. Erdmann. Qtlizer: comprehensive QTL annotation of GWAS results. Sci. Rep. 2020
- I. Wohlers, A. Kuenstner, M. Munz, M. Olbrich, A. Faehnrich, V. Calonga-Solís, C. Ma, M. Hirose, S. El-Mosallamy, M. Salama, H. Busch and S. Ibrahim. A personal and population-based Egyptian genome reference. Nat. Commun. 2020
- S. T. Jünger, F. Andreiuolo, M. Mynarek, I. Wohlers, S. Rahmann, L. Klein-Hitpass, E. Dörner, A. Zur Mühlen, N. Velez-Char, K. von Hoff, M. Warmuth-Metz, R. D. Kortmann, B. Timmermann, A. von Bueren, S. Rutkowski, T. Pietsch. CDKN2A deletion in supratentorial ependymoma with RELA alteration indicates a dismal prognosis: a retrospective analysis of the HIT ependymoma trial cohort. Acta Neuropathol. 2020
- S. T. Jünger, M. Mynarek, I. Wohlers, E. Dörner, A. zur Mühlen, N. Velez-Char, K. von Hoff, S. Rutkowski, M. Warmuth-Metz, R.-D. Kortmann, B. Timmermann, S. Rahmann, L. Klein-Hitpass, A. von Bueren, T. Pietsch. Improved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features – a retrospective analysis of the HIT ependymoma trial cohort. Acta Neuropathol. Commun. 2019
- I. Wohlers, C. Schulz, F. Kilpert, L. Bertram.
Alzheimer’s disease risk SNPs show no strong effect on miRNA expression in human lymphoblastoid cell lines. Neurobiol. Aging. 2019 - P. Takousis*, A. Sadlon*, J. Schulz, I. Wohlers, V. Dobricic, L. Middleton, C. M. Lill, R. Perneczky, L. Bertram. (* joint first authors)
Differential expression of microRNAs in Alzheimer’s disease brain, blood and cerebrospinal fluid: a systematic review and meta-analysis. Alzheimer’s & Dementia. 2019 - J. Schulz*, P. Takousis*, I. Wohlers, I. O. G. Itua, V. Dobricic, G. Rücker, H. Binder, L. Middleton, J. P. A. Ioannidis, R. Perneczky, L. Bertram, C. M. Lill. (* joint first authors) Meta-analyses identify differentially expressed microRNAs in Parkinson’s disease. Ann Neurol. 2019
- I. Wohlers and L. Bertram. Taking genomics research to the next level: The Genotype-Tissue expression project. Mov Disord. 2018
- I. Wohlers, L. Bertram and C. M. Lill. Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using integrative bioinformatics. J Autoimmun. 2018
- B. Grüning* , R. Dale*, […] I. Wohlers […] and J. Köster. (* joint first authors) Bioconda: A sustainable and comprehensive software distribution for the life science. Nat Methods. 2018
- P. Johansson, A. Bergmann, S. Rahmann, I. Wohlers, R. Scholtysik, M. Przekopowitz, M. Seifert, G. Tschurtschenthaler, G. Webersinke, U. Jäger, R. Siebert, L. Klein-Hitpass, U. Dührsen, J. Dürig and R. Küppers. Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. Int J Cancer. 2016
- R. Andonov, H. Djidjev, G. W. Klau, M. Le Boudic-Jamin and I. Wohlers. Automatic Classification of Protein Structure Using the Maximum Contact Map Overlap Metric. Algorithms, Special issue Algorithmic Themes in Bioinformatics. 2015
- C. M. Lill, F. Luessi, A. Alcina, E. A. Sokolova, N. Ugidos, B. de la Hera, L. Guillot-Noël, S. Malhotra, E. Reinthaler, B.-M. M. Schjeide, J. Y. Mescheriakova, A. Mashychev, I. Wohlers et al. Genome-wide significant association with seven novel multiple sclerosis risk loci. J Med Genet. 2015
- T. Pietsch, I. Wohlers, T. Goschzik, V. Dreschmann, D. Denkhaus, E. Dörner, S. Rahmann, and L. Klein-Hitpass. Supratentorial ependymomas of childhood carry C11orf95–RELA fusions leading to pathological activation of the NF-κB signaling pathway. Acta Neuropathol. 2014
- M. El-Kebir*, T. Marschall*, I. Wohlers*, M. Patterson, J. Heringa, A. Schönhuth, and G. W. Klau. (* joint first authors) Mapping proteins in the presence of paralogs using units of coevolution. BMC Bioinformatics. 2013
- I. Wohlers, R. Andonov and G. W. Klau. DALIX: Optimal DALI protein structure alignment. IEEE/ACM Trans Comput Biol Bioinform. 2013
- I. Wohlers, N. Malod-Dognin, R. Andonov, and G. W. Klau. CSA: comprehensive comparison of pairwise protein structure alignments. Nucleic Acids Res. 2012
- I. Wohlers, R. Andonov, and G. W. Klau. Algorithm engineering for optimal alignment of protein structure distance matrices. Optimization Letters. 2011
- I. Wohlers, F. S. Domingues, and G. W. Klau. Towards optimal alignment of protein structure distance matrices. Bioinformatics. 2010
- I. Wohlers*, H. Stachelscheid*, J. Borstlap, K. Zeilinger, and J. C. Gerlach. (* joint first authors) The Characterization Tool: A knowledge-based stem cell, differentiated cell, and tissue database with a web-based analysis front-end. Stem Cell Res. 2009
Preprints
- A. Fähnrich*, I. Stephan*, M. Hirose, M. A. Awadelkareem, S. Ibrahim, H. Busch§ and I. Wohlers§. (*joint first authors; §joint last authors) North and East African mitochondrial genetic variation needs further characterization towards precision medicine. bioRxiv 2021.12.10.472079. 2021
- I. Wohlers, V. Calonga-Solís, J.-N. Jobst and H. Busch. COVID-19 genetic risk and Neanderthals: A case study highlighting the importance of scrutinizing diversity. bioRxiv 2020.11.02.365551. 2020